What have we learned from a 10-year experience with the lumina (Lupus in Minorities; Nature vs. nurture) cohort? Where are we heading?

Recently, there has been an awareness of the variable phenotypic expression of numerous disorders between individuals from different ethnicities, systemic lupus erythematosus (SLE) one of them. These disparities probably arise from the interaction between genetic and non-genetic (environmental, soci...

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Veröffentlicht in:	Autoimmunity reviews 2004-06, Vol.3 (4), p.321-329
Hauptverfasser:	Uribe, América G, McGwin, Gerald, Reveille, John D, Alarcón, Graciela S
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans Alleles Cohort Studies Complement C4a - genetics Ethnic Groups Ethnicity European Continental Ancestry Group Female Forecasting Hispanic Americans HLA-DR Antigens - genetics Humans Longitudinal Studies LUMINA Lupus Erythematosus, Systemic - ethnology Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - pathology Male Multicenter Studies as Topic Outcome Socioeconomic Socioeconomic Factors Systemic lupus erythematosus United States
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Zusammenfassung:	Recently, there has been an awareness of the variable phenotypic expression of numerous disorders between individuals from different ethnicities, systemic lupus erythematosus (SLE) one of them. These disparities probably arise from the interaction between genetic and non-genetic (environmental, socioeconomic–demographic, cultural and behavioral) factors. To delineate the influence of these factors on SLE outcome, we established a multiethnic (Hispanic, African American and Caucasian) United States (US) early cohort (
ISSN:	1568-9972 1568-9972
DOI:	10.1016/j.autrev.2003.11.005