Exercise training and sympathetic regulation in experimental heart failure

In this review, we put forth the hypothesis that reduction in sympathetic outflow after exercise training of animals with heart failure is mediated by reductions in angiotensin II and in angiotensin type 1 receptors. Furthermore, we provide evidence that exercise training provides for an upregulatio...

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Veröffentlicht in:	Exercise and sport sciences reviews 2004-07, Vol.32 (3), p.107-111
Hauptverfasser:	Zucker, Irving H, Patel, Kaushik P, Schultz, Harold D, Li, Yi-Fan, Wang, Wei, Pliquett, Rainer U
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - metabolism Animals Baroreflex - physiology Disease Models, Animal Heart Failure - enzymology Heart Failure - metabolism Heart Failure - physiopathology Nitric Oxide - metabolism Nitric Oxide Synthase - metabolism Physical Conditioning, Animal - physiology Rabbits Receptor, Angiotensin, Type 1 - metabolism Sympathetic Nervous System - physiopathology
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Zusammenfassung:	In this review, we put forth the hypothesis that reduction in sympathetic outflow after exercise training of animals with heart failure is mediated by reductions in angiotensin II and in angiotensin type 1 receptors. Furthermore, we provide evidence that exercise training provides for an upregulation of the neuronal isoform of nitric oxide synthase in the central nervous system that is sympathoinhibitory.
ISSN:	0091-6331
DOI:	10.1097/00003677-200407000-00006