Adaptation of cardiac myocyte contractile properties to exercise training

Recent work suggests that chronic exercise induces alterations in the contractile properties of cardiac myocytes. These alterations include increased sensitivity to activation by Ca, changes in the force-length relationship, and increased power output. A recently observed shift in expression of myos...

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Veröffentlicht in:	Exercise and sport sciences reviews 2004-07, Vol.32 (3), p.112-119
1. Verfasser:	Diffee, Gary M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Animals Calcium - metabolism Calcium - pharmacology Cell Size - drug effects Heart - drug effects Heart - physiology Models, Biological Myocardial Contraction - drug effects Myocardium - metabolism Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - physiology Physical Conditioning, Animal - physiology Rats
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Zusammenfassung:	Recent work suggests that chronic exercise induces alterations in the contractile properties of cardiac myocytes. These alterations include increased sensitivity to activation by Ca, changes in the force-length relationship, and increased power output. A recently observed shift in expression of myosin light chain 1 subunit isoforms induced by training may provide a molecular mechanism for these contractile alterations.
ISSN:	0091-6331
DOI:	10.1097/00003677-200407000-00007