Anti-crosslinking properties of carnosine: Significance of histidine

Carnosine, a histidine-containing dipeptide, is a potential treatment for Alzheimer's disease. There is evidence that carnosine prevents oxidation and glycation, both of which contribute to the crosslinking of proteins; and protein crosslinking promotes β-amyloid plaque formation. It was previo...

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Veröffentlicht in:	Life sciences (1973) 2004-07, Vol.75 (11), p.1379-1389
Hauptverfasser:	Hobart, Laura J., Seibel, Ines, Yeargans, George S., Seidler, Norbert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced glycation endproduct (AGE) beta-Alanine - chemistry Carnosine Carnosine - chemistry Cross-Linking Reagents - chemistry Electrophoresis, Polyacrylamide Gel Glycosylation Histidine Histidine - chemistry In Vitro Techniques β-Alanine
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