Gonadotropin treatment of an azoospermic patient with a Y-chromosome microdeletion

To report on the treatment with recombinant FSH of an azoospermic normogonadotropic patient with a Y-chromosome microdeletion. Case report. An assisted reproduction center. A 32-year-old patient with azoospermia. Histological testicular biopsy, Y-chromosome screening, FSH treatment, and intracytoplasmic sperm injection. Fertilization, embryo development, pregnancy, and delivery. After 6 months of treatment with gonadotropins, a small number of spermatozoa were found in the patient's ejaculate and used for IVF, resulting in a successful twin pregnancy and the delivery of two healthy girls. In this study, treatment with gonadotropins promoted the spermatogenesis process and led to the production of spermatozoa in a normogonadotropic azoospermic patient.