Multiplexed assays for identification of biomarkers and surrogate markers in systemic lupus erythematosus

Validated biomarkers and surrogate markers are badly needed for monitoring patients with systemic lupus erythematosus (SLE), both for routine clinical care and for clinical trials research. SLE is difficult to study in clinical trials, in part because the disease is so heterogeneous. Very few useful...

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Veröffentlicht in:Lupus 2004-01, Vol.13 (5), p.304-311
1. Verfasser: Utz, P J
Format: Artikel
Sprache:eng
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Zusammenfassung:Validated biomarkers and surrogate markers are badly needed for monitoring patients with systemic lupus erythematosus (SLE), both for routine clinical care and for clinical trials research. SLE is difficult to study in clinical trials, in part because the disease is so heterogeneous. Very few useful markers have been identified, and even those that historicallyhave been thought to be valid have been recently questioned. This report will focus on the use of emerging multiplexed assay formats that enable analysis of hundreds or even thousands of analytes simultaneously. Their potential and pitfalls for monitoring patients with SLE, particularly those enrolled in clinical trials testing novel therapeutics, will be discussed.
ISSN:0961-2033
1477-0962
DOI:10.1191/0961203303lu1017oa