Nataxazole, a New Benzoxazole Derivative with Antitumor Activity Produced by Streptomyces sp. Tü 6176

The new benzoxazole derivative nataxazole was isolated from Streptomyces sp. (strain Tü 6176). Nataxazole is related in structure to the potent antitumor compounds UK-1 and AJI9561 and showed similar strong growth inhibitory activity against various human tumor cell lines.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 2008-11, Vol.61 (11), p.683-686
Hauptverfasser:	Sommer, Patricia S M, Almeida, Rosemary C, Schneider, Kathrin, Beil, Winfried, Süssmuth, Roderich D, Fiedler, Hans-Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Bacteriology Benzoxazoles - chemistry Benzoxazoles - isolation & purification Benzoxazoles - pharmacology Biomedical and Life Sciences Bioorganic Chemistry Cell Line, Tumor Humans Life Sciences Medicinal Chemistry Microbiology Molecular Structure Organic Chemistry Streptomyces - chemistry Streptomyces - metabolism
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Beschreibung
Zusammenfassung:	The new benzoxazole derivative nataxazole was isolated from Streptomyces sp. (strain Tü 6176). Nataxazole is related in structure to the potent antitumor compounds UK-1 and AJI9561 and showed similar strong growth inhibitory activity against various human tumor cell lines.
ISSN:	0021-8820 1881-1469
DOI:	10.1038/ja.2008.97