Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains

A series of benzoxathiin SERAMs was prepared. Minor modifications in the side chain resulted in significant effects on biological activity, especially in uterine tissue. A series of benzoxathiin SERAMs with bicyclic amine side chains was prepared. Minor modifications in the side chain resulted in si...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2004-08, Vol.14 (15), p.3861-3864
Hauptverfasser:	Blizzard, Timothy A, DiNinno, Frank, Morgan, Jerry D, Chen, Helen Y, Wu, Jane Y, Gude, Candido, Kim, Seongkon, Chan, Wanda, Birzin, Elizabeth T, Tien Yang, Yi, Pai, Lee-Yuh, Zhang, Zhoupeng, Hayes, Edward C, DaSilva, Carolyn A, Tang, Wei, Rohrer, Susan P, Schaeffer, James M, Hammond, Milton L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bridged Bicyclo Compounds - chemistry Bridged Bicyclo Compounds - pharmacology Estrogen Female Hormones. Endocrine system Kinetics Ligands Medical sciences Miscellaneous Models, Molecular Molecular Conformation Pharmacology. Drug treatments Receptors, Estrogen - metabolism Selective Estrogen Receptor Modulators - chemistry Selective Estrogen Receptor Modulators - metabolism Selective Estrogen Receptor Modulators - pharmacology SERAMs SERMs Structure-Activity Relationship Uterus - drug effects
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Zusammenfassung:	A series of benzoxathiin SERAMs was prepared. Minor modifications in the side chain resulted in significant effects on biological activity, especially in uterine tissue. A series of benzoxathiin SERAMs with bicyclic amine side chains was prepared. Minor modifications in the side chain resulted in significant effects on biological activity, especially in uterine tissue.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2004.05.074