Transfer of insulin lispro across the human placenta

Transfer of insulin lispro across the human placenta

Our in vitro perfusion study confirms the result of the Boskovic et al., that insulin lispo is not crossing the human placental membranes at low concentrations. In our study maternal steady state concentration reached 48±0.7 μU in the maternal artery and 28±1 μU in the maternal vein, while in the fe...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European journal of obstetrics & gynecology and reproductive biology 2004-07, Vol.115 (1), p.117-118
Hauptverfasser: Holcberg, Gershon, Tsadkin-Tamir, Marina, Sapir, Olga, Wiznizer, Arnon, Segal, David, Polachek, Hana, Ben Zvi, Zvi
Format: Artikel
Sprache:eng
Schlagworte:
Female
Human placenta
Humans
Insulin - analogs & derivatives
Insulin - analysis
Insulin - blood
Insulin Lispro
Maternal-Fetal Exchange
Perfusion
Placenta - chemistry
Placenta - metabolism
Pregnancy
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Our in vitro perfusion study confirms the result of the Boskovic et al., that insulin lispo is not crossing the human placental membranes at low concentrations. In our study maternal steady state concentration reached 48±0.7 μU in the maternal artery and 28±1 μU in the maternal vein, while in the fetal site insulin lispo was not detected. However, the concentration of insulin lispo in placental tissue was 1836±220 μU.
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2003.10.006