Differential associations of residual estradiol levels with bone mineral density and serum lipids in postmenopausal women with osteoporosis
Objectives: To examine the associations of residual endogenous estradiol (E 2) to bone mineral density (BMD) and lipid concentrations in elderly women. Methods: Subjects consisted of 59 elderly postmenopausal women with vertebral or femoral osteoporosis. BMD was measured at L2-4 and femoral neck by...
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| Veröffentlicht in: | Maturitas 2004-07, Vol.48 (3), p.193-196 |
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| creator | Ongphiphadhanakul, B Chanprasertyothin, S Chailurkit, L Chansirikarn, S Puavilai, G Rajatanavin, R |
| description | Objectives: To examine the associations of residual endogenous estradiol (E
2) to bone mineral density (BMD) and lipid concentrations in elderly women.
Methods: Subjects consisted of 59 elderly postmenopausal women with vertebral or femoral osteoporosis. BMD was measured at L2-4 and femoral neck by dual-energy X-ray absorptiometry (DEXA). Residual E
2 concentrations were assessed by a sensitive radioimmunoassay. Data were expressed as mean±S.E.M.
Results: The age of the subjects was 65.2±0.8 years with 18.9±1.0 years postmenopausal. The mean residual E
2 concentration was 6.0±0.5
pg/ml. There was a correlation between E
2 levels and BMD at L2-4 (
r=0.32,
P |
| doi_str_mv | 10.1016/j.maturitas.2003.08.007 |
| format | Article |
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2) to bone mineral density (BMD) and lipid concentrations in elderly women.
Methods: Subjects consisted of 59 elderly postmenopausal women with vertebral or femoral osteoporosis. BMD was measured at L2-4 and femoral neck by dual-energy X-ray absorptiometry (DEXA). Residual E
2 concentrations were assessed by a sensitive radioimmunoassay. Data were expressed as mean±S.E.M.
Results: The age of the subjects was 65.2±0.8 years with 18.9±1.0 years postmenopausal. The mean residual E
2 concentration was 6.0±0.5
pg/ml. There was a correlation between E
2 levels and BMD at L2-4 (
r=0.32,
P<0.01) while no association was found at the femoral neck. The association between E
2 and L2-4 BMD persisted after adjusting for years since menopause and body weight (
r=0.33,
P<0.05). With regard to serum lipid concentrations, no association of serum total cholesterol, LDL-cholesterol, HDL-cholesterol or triglyceride concentrations with residual E
2 was found.
Conclusions: Our findings confirm the role of residual endogenous E
2 in the determination of bone mass in postmenopausal women with osteoporosis. The effect of residual E
2 appears to be skeletal specific and possess no association with serum lipid concentrations.</description><identifier>ISSN: 0378-5122</identifier><identifier>EISSN: 1873-4111</identifier><identifier>DOI: 10.1016/j.maturitas.2003.08.007</identifier><identifier>PMID: 15207884</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Absorptiometry, Photon ; Aged ; Aged, 80 and over ; Bone Density - physiology ; Dyslipidemia ; Estradiol - blood ; Female ; Femur Neck ; Humans ; Lipids - blood ; Lumbar Vertebrae ; Menopause ; Middle Aged ; Osteoporosis ; Osteoporosis, Postmenopausal - blood ; Radioimmunoassay ; Residual estrogen</subject><ispartof>Maturitas, 2004-07, Vol.48 (3), p.193-196</ispartof><rights>2003 Elsevier Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-5ff72afc2b332abd3c2b417c41dc85e297559313808d9d55421477ccddd3e2f3</citedby><cites>FETCH-LOGICAL-c367t-5ff72afc2b332abd3c2b417c41dc85e297559313808d9d55421477ccddd3e2f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.maturitas.2003.08.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15207884$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ongphiphadhanakul, B</creatorcontrib><creatorcontrib>Chanprasertyothin, S</creatorcontrib><creatorcontrib>Chailurkit, L</creatorcontrib><creatorcontrib>Chansirikarn, S</creatorcontrib><creatorcontrib>Puavilai, G</creatorcontrib><creatorcontrib>Rajatanavin, R</creatorcontrib><title>Differential associations of residual estradiol levels with bone mineral density and serum lipids in postmenopausal women with osteoporosis</title><title>Maturitas</title><addtitle>Maturitas</addtitle><description>Objectives: To examine the associations of residual endogenous estradiol (E
2) to bone mineral density (BMD) and lipid concentrations in elderly women.
Methods: Subjects consisted of 59 elderly postmenopausal women with vertebral or femoral osteoporosis. BMD was measured at L2-4 and femoral neck by dual-energy X-ray absorptiometry (DEXA). Residual E
2 concentrations were assessed by a sensitive radioimmunoassay. Data were expressed as mean±S.E.M.
Results: The age of the subjects was 65.2±0.8 years with 18.9±1.0 years postmenopausal. The mean residual E
2 concentration was 6.0±0.5
pg/ml. There was a correlation between E
2 levels and BMD at L2-4 (
r=0.32,
P<0.01) while no association was found at the femoral neck. The association between E
2 and L2-4 BMD persisted after adjusting for years since menopause and body weight (
r=0.33,
P<0.05). With regard to serum lipid concentrations, no association of serum total cholesterol, LDL-cholesterol, HDL-cholesterol or triglyceride concentrations with residual E
2 was found.
Conclusions: Our findings confirm the role of residual endogenous E
2 in the determination of bone mass in postmenopausal women with osteoporosis. The effect of residual E
2 appears to be skeletal specific and possess no association with serum lipid concentrations.</description><subject>Absorptiometry, Photon</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bone Density - physiology</subject><subject>Dyslipidemia</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>Femur Neck</subject><subject>Humans</subject><subject>Lipids - blood</subject><subject>Lumbar Vertebrae</subject><subject>Menopause</subject><subject>Middle Aged</subject><subject>Osteoporosis</subject><subject>Osteoporosis, Postmenopausal - blood</subject><subject>Radioimmunoassay</subject><subject>Residual estrogen</subject><issn>0378-5122</issn><issn>1873-4111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxi0EotvCK4BP3BL8J46zx6oUqFSJS--W156IWSV28CSt-gy8NK52BUdO49H85pvxfIx9lKKVQvafj-3s163g6qlVQuhWDK0Q9hXbycHqppNSvmY7oe3QGKnUBbskOgohjNDdW3YhjRJ2GLod-_0FxxEKpBX9xD1RDuhXzIl4HnkBwrjVAtBafMQ88QkeYSL-hOtPfsgJ-IwJSkUiJML1mfsUOUHZZj7hgpE4Jr5kWmdIefEbVfQp1-QkUQuQl1wyIb1jb0Y_Ebw_xyv28PX24eZ7c__j293N9X0TdG_XxoyjVX4M6qC18oeo66uTNnQyhsGA2ltj9lrqQQxxH43plOysDSHGqEGN-op9OskuJf_a6s_cjBRgmnyCvJHr-97YKlhBewJDXY8KjG4pOPvy7KRwLza4o_trg3uxwYnBVRtq54fziO0wQ_zXd757Ba5PQL0lPCIURwEhBYhYIKwuZvzvkD_BZKKD</recordid><startdate>20040715</startdate><enddate>20040715</enddate><creator>Ongphiphadhanakul, B</creator><creator>Chanprasertyothin, S</creator><creator>Chailurkit, L</creator><creator>Chansirikarn, S</creator><creator>Puavilai, G</creator><creator>Rajatanavin, R</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040715</creationdate><title>Differential associations of residual estradiol levels with bone mineral density and serum lipids in postmenopausal women with osteoporosis</title><author>Ongphiphadhanakul, B ; Chanprasertyothin, S ; Chailurkit, L ; Chansirikarn, S ; Puavilai, G ; Rajatanavin, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-5ff72afc2b332abd3c2b417c41dc85e297559313808d9d55421477ccddd3e2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Absorptiometry, Photon</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bone Density - physiology</topic><topic>Dyslipidemia</topic><topic>Estradiol - blood</topic><topic>Female</topic><topic>Femur Neck</topic><topic>Humans</topic><topic>Lipids - blood</topic><topic>Lumbar Vertebrae</topic><topic>Menopause</topic><topic>Middle Aged</topic><topic>Osteoporosis</topic><topic>Osteoporosis, Postmenopausal - blood</topic><topic>Radioimmunoassay</topic><topic>Residual estrogen</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ongphiphadhanakul, B</creatorcontrib><creatorcontrib>Chanprasertyothin, S</creatorcontrib><creatorcontrib>Chailurkit, L</creatorcontrib><creatorcontrib>Chansirikarn, S</creatorcontrib><creatorcontrib>Puavilai, G</creatorcontrib><creatorcontrib>Rajatanavin, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Maturitas</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ongphiphadhanakul, B</au><au>Chanprasertyothin, S</au><au>Chailurkit, L</au><au>Chansirikarn, S</au><au>Puavilai, G</au><au>Rajatanavin, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential associations of residual estradiol levels with bone mineral density and serum lipids in postmenopausal women with osteoporosis</atitle><jtitle>Maturitas</jtitle><addtitle>Maturitas</addtitle><date>2004-07-15</date><risdate>2004</risdate><volume>48</volume><issue>3</issue><spage>193</spage><epage>196</epage><pages>193-196</pages><issn>0378-5122</issn><eissn>1873-4111</eissn><abstract>Objectives: To examine the associations of residual endogenous estradiol (E
2) to bone mineral density (BMD) and lipid concentrations in elderly women.
Methods: Subjects consisted of 59 elderly postmenopausal women with vertebral or femoral osteoporosis. BMD was measured at L2-4 and femoral neck by dual-energy X-ray absorptiometry (DEXA). Residual E
2 concentrations were assessed by a sensitive radioimmunoassay. Data were expressed as mean±S.E.M.
Results: The age of the subjects was 65.2±0.8 years with 18.9±1.0 years postmenopausal. The mean residual E
2 concentration was 6.0±0.5
pg/ml. There was a correlation between E
2 levels and BMD at L2-4 (
r=0.32,
P<0.01) while no association was found at the femoral neck. The association between E
2 and L2-4 BMD persisted after adjusting for years since menopause and body weight (
r=0.33,
P<0.05). With regard to serum lipid concentrations, no association of serum total cholesterol, LDL-cholesterol, HDL-cholesterol or triglyceride concentrations with residual E
2 was found.
Conclusions: Our findings confirm the role of residual endogenous E
2 in the determination of bone mass in postmenopausal women with osteoporosis. The effect of residual E
2 appears to be skeletal specific and possess no association with serum lipid concentrations.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>15207884</pmid><doi>10.1016/j.maturitas.2003.08.007</doi><tpages>4</tpages></addata></record> |
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| ispartof | Maturitas, 2004-07, Vol.48 (3), p.193-196 |
| issn | 0378-5122 1873-4111 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66657417 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Absorptiometry, Photon Aged Aged, 80 and over Bone Density - physiology Dyslipidemia Estradiol - blood Female Femur Neck Humans Lipids - blood Lumbar Vertebrae Menopause Middle Aged Osteoporosis Osteoporosis, Postmenopausal - blood Radioimmunoassay Residual estrogen |
| title | Differential associations of residual estradiol levels with bone mineral density and serum lipids in postmenopausal women with osteoporosis |
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