Differential associations of residual estradiol levels with bone mineral density and serum lipids in postmenopausal women with osteoporosis

Objectives: To examine the associations of residual endogenous estradiol (E 2) to bone mineral density (BMD) and lipid concentrations in elderly women. Methods: Subjects consisted of 59 elderly postmenopausal women with vertebral or femoral osteoporosis. BMD was measured at L2-4 and femoral neck by dual-energy X-ray absorptiometry (DEXA). Residual E 2 concentrations were assessed by a sensitive radioimmunoassay. Data were expressed as mean±S.E.M. Results: The age of the subjects was 65.2±0.8 years with 18.9±1.0 years postmenopausal. The mean residual E 2 concentration was 6.0±0.5 pg/ml. There was a correlation between E 2 levels and BMD at L2-4 ( r=0.32, P