Quantification in positron emission tomography for research in pharmacology and drug development
Positron emission tomography (PET) is a quantitative in vivo tracer technique, enabling images of the distribution of biochemical, physiological and pharmacological functions in living tissue, at a resolution of a few millimetres. Applications include the imaging of blood flow rate, metabolic rate a...
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| Veröffentlicht in: | Nuclear medicine communications 2004-07, Vol.25 (7), p.643-646 |
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| container_title | Nuclear medicine communications |
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| creator | Cunningham, V.J Gunn, R.N Matthews, J.C |
| description | Positron emission tomography (PET) is a quantitative in vivo tracer technique, enabling images of the distribution of biochemical, physiological and pharmacological functions in living tissue, at a resolution of a few millimetres. Applications include the imaging of blood flow rate, metabolic rate and neuroreceptor distribution and function. These applications are playing an increasing role in drug development. This brief article seeks to emphasize how these applications of PET need to rest on a solid quantitative foundation. |
| doi_str_mv | 10.1097/01.mnm.0000134330.38536.bc |
| format | Article |
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| identifier | ISSN: 0143-3636 |
| ispartof | Nuclear medicine communications, 2004-07, Vol.25 (7), p.643-646 |
| issn | 0143-3636 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Algorithms Animals Brain - blood supply Brain - diagnostic imaging Brain - metabolism Brain Mapping - methods Drug Design Fluorodeoxyglucose F18 - pharmacokinetics Humans Image Enhancement - methods Image Interpretation, Computer-Assisted - methods Pharmacology - methods Positron-Emission Tomography - methods Positron-Emission Tomography - trends Radiopharmaceuticals - pharmacokinetics Research Design Sensory Receptor Cells - metabolism |
| title | Quantification in positron emission tomography for research in pharmacology and drug development |
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