Quantification in positron emission tomography for research in pharmacology and drug development

Positron emission tomography (PET) is a quantitative in vivo tracer technique, enabling images of the distribution of biochemical, physiological and pharmacological functions in living tissue, at a resolution of a few millimetres. Applications include the imaging of blood flow rate, metabolic rate a...

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Veröffentlicht in:Nuclear medicine communications 2004-07, Vol.25 (7), p.643-646
Hauptverfasser: Cunningham, V.J, Gunn, R.N, Matthews, J.C
Format: Artikel
Sprache:eng
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Zusammenfassung:Positron emission tomography (PET) is a quantitative in vivo tracer technique, enabling images of the distribution of biochemical, physiological and pharmacological functions in living tissue, at a resolution of a few millimetres. Applications include the imaging of blood flow rate, metabolic rate and neuroreceptor distribution and function. These applications are playing an increasing role in drug development. This brief article seeks to emphasize how these applications of PET need to rest on a solid quantitative foundation.
ISSN:0143-3636
DOI:10.1097/01.mnm.0000134330.38536.bc