A case of T-cell acute lymphoblastic leukemia after treatment of acute promyelocytic leukemia

We diagnosed T-cell acute lymphoblastic leukemia (T-ALL) with multiple cytogenetic abnormalities in a 17-year-old girl a year after she had received a diagnosis of acute promyelocytic leukemia (APML). After the diagnosis of APML in June 2001, the patient was treated with idarubicin and all-trans-ret...

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Veröffentlicht in:	International journal of hematology 2004-05, Vol.79 (4), p.358-360
Hauptverfasser:	BEE, P. C, GAN, G. G, SANGKAR, J. V, TEH, A, GOH, K. Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Biological and medical sciences Cytogenetic Analysis Family Health Fatal Outcome Female Hematologic and hematopoietic diseases Humans Idarubicin - therapeutic use Leukemia Leukemia, Promyelocytic, Acute - diagnosis Leukemia, Promyelocytic, Acute - drug therapy Leukemia-Lymphoma, Adult T-Cell - diagnosis Leukemia-Lymphoma, Adult T-Cell - etiology Leukemia-Lymphoma, Adult T-Cell - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Neoplasms, Second Primary - diagnosis Neoplasms, Second Primary - etiology Opportunistic Infections - etiology Siblings Tretinoin - therapeutic use
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Zusammenfassung:	We diagnosed T-cell acute lymphoblastic leukemia (T-ALL) with multiple cytogenetic abnormalities in a 17-year-old girl a year after she had received a diagnosis of acute promyelocytic leukemia (APML). After the diagnosis of APML in June 2001, the patient was treated with idarubicin and all-trans-retinoic acid. In September 1999, her younger sister also received a diagnosis of APML and to date has remained well. T-ALL after remission of APML is very rare, and only 1 such case has been reported. Possible causes include therapy-related reasons, genetic susceptibility to leukemia, and environmental exposure.
ISSN:	0925-5710 1865-3774
DOI:	10.1532/IJH97.A20304