Glycosphingolipids in endocytic membrane transport

Endocytosis leads to the internalisation of both lipids and proteins and their delivery to specific subcellular locations. This involves sorting processes that are not completely understood, but may involve interactions between lipids and proteins as well as pH and calcium gradients. This article di...

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Veröffentlicht in:Seminars in cell & developmental biology 2004-08, Vol.15 (4), p.409-416
Hauptverfasser: Sillence, Dan J, Platt, Frances M
Format: Artikel
Sprache:eng
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Zusammenfassung:Endocytosis leads to the internalisation of both lipids and proteins and their delivery to specific subcellular locations. This involves sorting processes that are not completely understood, but may involve interactions between lipids and proteins as well as pH and calcium gradients. This article discusses the importance of endocytosis in glycosphingolipid (GSL) synthesis as well as the potential roles of GSLs in endocytic membrane transport. Although the accumulation of GSLs in storage diseases clearly disrupts endocytic transport, increasing evidence also supports a role for GSLs in endocytosis in normal cells.
ISSN:1084-9521
1096-3634
DOI:10.1016/j.semcdb.2004.03.004