Emergence of Carbapenem-Resistant Klebsiella Species Possessing the Class A Carbapenem-Hydrolyzing KPC-2 and Inhibitor-Resistant TEM-30 β-Lactamases in New York City

Nineteen isolates of carbapenem-resistant Klebsiella species were recovered from 7 hospitals in New York City. Most K. pneumoniae belonged to a single ribotype. Nucleotide sequencing identified KPC-2, a carbapenem-hydrolyzing β-lactamase. In 3 strains, TEM-30, an inhibitor-resistant β-lactamase, was...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical infectious diseases 2004-07, Vol.39 (1), p.55-60
Hauptverfasser:	Bradford, Patricia A., Bratu, Simona, Urban, Carl, Visalli, Melissa, Mariano, Noriel, Landman, David, Rahal, James J., Brooks, Steven, Cebular, Sanda, Quale, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobials beta-Lactam Resistance - physiology beta-Lactamases - metabolism Biological and medical sciences Carbapenems Carbapenems - metabolism Carbapenems - pharmacology Drug Resistance, Bacterial Enzymes Humans Infections Klebsiella Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - enzymology Klebsiella pneumoniae - isolation & purification Major Articles Medical sciences Microbial Sensitivity Tests New York City Nucleotides Pharmacology. Drug treatments Ribotyping Sequencing
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Nineteen isolates of carbapenem-resistant Klebsiella species were recovered from 7 hospitals in New York City. Most K. pneumoniae belonged to a single ribotype. Nucleotide sequencing identified KPC-2, a carbapenem-hydrolyzing β-lactamase. In 3 strains, TEM-30, an inhibitor-resistant β-lactamase, was detected. Carbapenem-resistant Klebsiella species possessing KPC-2 are endemic in New York City. This study documents the identification of an inhibitor-resistant TEM β-lactamase in the United States.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/421495