An atomic force microscopy study of the effect of nanoscale contact geometry and surface chemistry on the adhesion of pharmaceutical particles

To understand differences in particle adhesion observed with increasing humidity between samples of salbutamol sulfate prepared by two different methods. Atomic force microscopy (AFM) force measurements were performed as a function of humidity (

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Bibliographische Detailangaben
Veröffentlicht in:	Pharmaceutical research 2004-06, Vol.21 (6), p.953-961
Hauptverfasser:	Hooton, Jennifer C, German, Caroline S, Allen, Stephanie, Davies, Martyn C, Roberts, Clive J, Tendler, Saul J B, Williams, Philip M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesiveness Albuterol - chemistry Algorithms Chemistry, Pharmaceutical - methods Chromatography, Supercritical Fluid - methods Friction Graphite - chemistry Humidity Microscopy, Atomic Force - instrumentation Microscopy, Atomic Force - methods Nanotechnology - methods Particle Size Powders - chemistry Solubility Technology, Pharmaceutical - methods
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Beschreibung
Zusammenfassung:	To understand differences in particle adhesion observed with increasing humidity between samples of salbutamol sulfate prepared by two different methods. Atomic force microscopy (AFM) force measurements were performed as a function of humidity (
ISSN:	0724-8741 1573-904X
DOI:	10.1023/B:PHAM.0000029283.47643.9c