Interstrand communication between 2'-N-(pyren-1-yl)methyl-2'-amino-LNA monomers in nucleic acid duplexes: directional control and signalling of full complementarity

Very efficient interstrand communication systems in nucleic acid duplexes, based on pyrene excimer formation between 2'-N-(pyren-1-yl)methyl-2'-amino-LNA monomers, demonstrate the versatility of functionalized 2'-amino-LNA monomers for Angstrom-scale chemical engineering.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2004-07 (13), p.1478-1479
Hauptverfasser:	Hrdlicka, Patrick J, Babu, B Ravindra, Sørensen, Mads D, Wengel, Jesper
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Pair Mismatch Chemical Engineering - methods DNA Probes DNA, Complementary - chemistry Hot Temperature Molecular Structure Nucleic Acid Conformation Nucleic Acid Denaturation Nucleic Acids - chemistry Oligonucleotides Oligonucleotides, Antisense - chemistry Pyrenes - chemistry Spectrometry, Fluorescence
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Beschreibung
Zusammenfassung:	Very efficient interstrand communication systems in nucleic acid duplexes, based on pyrene excimer formation between 2'-N-(pyren-1-yl)methyl-2'-amino-LNA monomers, demonstrate the versatility of functionalized 2'-amino-LNA monomers for Angstrom-scale chemical engineering.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/b404446k