Design, synthesis and cytotoxic studies on the simplified oxy analog of eleutherobin

Design, synthesis and cytotoxic studies on the simplified oxy analog of eleutherobin

A straight forward entry into nine membered B ring of eleutherobin as oxy analog and its cyctotoxic properties on HBL cell lines is described. Molecular modeling studies were carried out to ascertain the binding of the model compound to the active site of beta-tubulin.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Bioorganic & medicinal chemistry letters 2004-07, Vol.14 (14), p.3687-3689
Hauptverfasser: CHANDRASEKHAR, S, JAGADESHWAR, V, NARSIHMULU, Ch, SARANGAPANI, M, KRISHNA, D. R, VIDYASAGAR, J, VIJAY, Dolly, NARAHARI SASTRY, G
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic agents
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - pharmacology
Binding Sites
Biological and medical sciences
Diterpenes - chemical synthesis
Diterpenes - pharmacology
Drug Design
Female
General aspects
Humans
Medical sciences
Molecular Conformation
Pharmacology. Drug treatments
Tubulin - chemistry
Tubulin - metabolism
Tumor Cells, Cultured
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A straight forward entry into nine membered B ring of eleutherobin as oxy analog and its cyctotoxic properties on HBL cell lines is described. Molecular modeling studies were carried out to ascertain the binding of the model compound to the active site of beta-tubulin.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2004.05.017