A Novel Method for the Preparation of Nucleoside Triphosphates from Activated Nucleoside Phosphoramidates

A Novel Method for the Preparation of Nucleoside Triphosphates from Activated Nucleoside Phosphoramidates

A novel method for the preparation of nucleoside triphosphates has been developed. The strategy employs a highly reactive pyrrolidinium phosphoramidate zwitterion intermediate that undergoes efficient coupling with tris(tetra-n-butylammonium) hydrogen pyrophosphate to generate nucleoside triphosphat...

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Veröffentlicht in:Organic letters 2004-06, Vol.6 (13), p.2257-2260
Hauptverfasser: Wu, Weidong, Freel Meyers, Caren L, Borch, Richard F
Format: Artikel
Sprache:eng
Schlagworte:
Amides - chemical synthesis
Amides - chemistry
Diphosphates - chemistry
Nucleotides - chemical synthesis
Phosphoric Acids - chemical synthesis
Phosphoric Acids - chemistry
Pyrrolidines - chemistry
Thymidine - chemistry
Thymine Nucleotides - chemistry
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Zusammenfassung:A novel method for the preparation of nucleoside triphosphates has been developed. The strategy employs a highly reactive pyrrolidinium phosphoramidate zwitterion intermediate that undergoes efficient coupling with tris(tetra-n-butylammonium) hydrogen pyrophosphate to generate nucleoside triphosphate.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol049267j