Involvement of Notch Signaling in Hippocampal Synaptic Plasticity

During development of the nervous system, the fate of stem cells is regulated by a cell surface receptor called Notch. Notch is also present in the adult mammalian brain; however, because Notch null mice die during embryonic development, it has proven difficult to determine the functions of Notch. H...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-06, Vol.101 (25), p.9458-9462
Hauptverfasser:	Wang, Yue, Chan, Sic L., Miele, Lucio, Yao, Pamela J., Mackes, Jennifer, Ingram, Donald K., Mattson, Mark P., Furukawa, Katsutoshi, Andersen, Per O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Brain research Hippocampus Hippocampus - physiology Learning - physiology Ligands Long term depression Long term potentiation Long-Term Potentiation - physiology Membrane Proteins - genetics Membrane Proteins - physiology Memory Memory - physiology Mice Mice, Transgenic Neurology Neuronal Plasticity - physiology Neurons Neuroscience Presenilins Receptors, Cell Surface - genetics Receptors, Cell Surface - physiology Receptors, Notch Rodents Signal transduction Synapses Synapses - physiology Transgenic animals
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