Family History of Psychiatric Disorders and Alcohol and Substance Misuse in Patients with Bipolar I Disorder, Substance Use Disorder, or Both

Family history data were collected on first-degree relatives of 78 patients with bipolar I disorder (BD) and substance use disorder (SUD), 47 with BD only, and 35 with SUD only. The prevalence of psychiatric disorders was significantly higher in first-degree relatives of patients with BD + SUD (64%)...

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Veröffentlicht in:The American journal on addictions 2007-05, Vol.16 (3), p.227-231
Hauptverfasser: Sbrana, Alfredo, Bizzarri, Jacopo V., Rucci, Paola, Gonnelli, Chiara, Massei, Jacopo G., Ravani, Laura, Endicott, Jean, Maser, Jack D., Cassano, Giovanni B.
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Sprache:eng
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Zusammenfassung:Family history data were collected on first-degree relatives of 78 patients with bipolar I disorder (BD) and substance use disorder (SUD), 47 with BD only, and 35 with SUD only. The prevalence of psychiatric disorders was significantly higher in first-degree relatives of patients with BD + SUD (64%) and BD (61%) compared with first-degree relatives of SUD patients (20%). The prevalence of alcohol misuse was significantly higher in first-degree relatives of patients with BD + SUD (23.1%) and SUD alone (28.6%) compared to first-degree relatives of patients with BD (4.3%). Our findings suggest that BD and SUD do not share familial risk factors. (Am J Addict 2007;16:227-231)
ISSN:1055-0496
1521-0391
DOI:10.1080/10550490701375699