Open label study of the effect of amantadine on weight gain induced by olanzapine

The purpose of the present paper was to investigate the effects of the dopamine agonist amantadine in those patients with weight gain induced by olanzapine. An open trial was conducted in those patients who gained >3 kg in weight induced by olanzapine use. All subjects were evaluated by weight, b...

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Veröffentlicht in:	Psychiatry and clinical neurosciences 2004-04, Vol.58 (2), p.163-167
Hauptverfasser:	BAHK, WON‐MYONG, LEE, KYOUNG‐UK, CHAE, JEONG‐HO, PAE, CHI‐UN, JUN, TAEYOUN, KIM, KWANG‐SOO
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amantadine Amantadine - adverse effects Amantadine - therapeutic use Antipsychotic Agents - adverse effects Antipsychotic Agents - therapeutic use Benzodiazepines - adverse effects Benzodiazepines - therapeutic use Biological and medical sciences Bipolar Disorder - drug therapy Body Mass Index Body Weight - drug effects Brief Psychiatric Rating Scale Depressive Disorder, Major - drug therapy Dopamine Agonists - adverse effects Dopamine Agonists - therapeutic use Dose-Response Relationship, Drug Drug Therapy, Combination Drug toxicity and drugs side effects treatment Female Humans Korea Male Medical sciences Middle Aged Miscellaneous (drug allergy, mutagens, teratogens...) Neurologic Examination - drug effects Olanzapine Pharmacology. Drug treatments Psychotic Disorders - drug therapy Schizophrenia - drug therapy Treatment Treatment Outcome Weight gain
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Zusammenfassung:	The purpose of the present paper was to investigate the effects of the dopamine agonist amantadine in those patients with weight gain induced by olanzapine. An open trial was conducted in those patients who gained >3 kg in weight induced by olanzapine use. All subjects were evaluated by weight, body mass index (BMI), the Brief Psychiatric Rating Scale (BPRS), and the Extrapyramidal Symptom Rating Scale (ESRS) before and after the use of amantadine in addition to olanzapine. Twenty‐five of 30 enrolled patients completed the present study. Mean bodyweight and BMI was increased by 6.44 ± 4.42 kg and 5.04 ± 3.47 kg/m2 significantly with olanzapine alone (P
ISSN:	1323-1316 1440-1819
DOI:	10.1111/j.1440-1819.2003.01211.x