Genetic variant of lactase-persistent C/T(sub -13910) is associated with bone fractures in very old age

OBJECTIVES: To determine the relation between the C/T(sub -13910) single-nucleotide polymorphism residing 13,910 base pairs from the S' end of the lactase gene associated with lactase persistence and the occurrence of bone fractures in elderly people. DESIGN: Population-based study. SETTING: Vantaa 85+ population-based study, including all 601 subjects born before April 1, 1906, who were living in the city of Vantaa, Finland, on April 1, 1991. PARTICIPANTS: Four hundred eighty-three people aged 85 and older (106 men and 377 women). MEASUREMENTS: Genotype determination was made using a polymerase chain reaction minisequencing technique. RESULTS: The frequency of the genotype C/C(sub -13910) associated with adult-type hypolactasia (low lactase enzyme activity or primary lactose malabsorption (LM)) was significantly greater in individuals with hip fractures, with an adjusted odds ratio (OR) of 3.7 (95% confidence interval (CI) = 1.8-7.8), wrist fractures with an adjusted OR of 2.5 (95% CI = 1.2-5.2), and hip and wrist fractures combined with an adjusted OR of 4.1 (95% CI = 2.0-8.3). CONCLUSION: The C/C(sub -13910) genotype associated with primary LM could represent a genetic risk factor for bone fractures for elderly people. (Original abstract