CORTISOL RESPONSE TO BUSPIRONE IN EXTENDED ABSTINENT ALCOHOLICS

CORTISOL RESPONSE TO BUSPIRONE IN EXTENDED ABSTINENT ALCOHOLICS

We evaluated cortisol response to buspirone in extended abstinent alcoholic patients to determine 5-HT1A receptor sensitivity in alcoholism. Alcoholic patients were inpatients with an extended abstinent period of at least 3 months. Alcoholics had a significantly lower cortisol level than did the nor...

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Veröffentlicht in:Alcohol and alcoholism (Oxford) 2004-07, Vol.39 (4), p.287-289
Hauptverfasser: KIM, YOUNG-HOON, SHIM, JOO-CHEOL, KELLY, DEANNA L., LEE, JEONG-GOO, SEO, YOUNG-SOO, CONLEY, ROBERT R.
Format: Artikel
Sprache:eng
Schlagworte:
Abstinence
Adult
Alcoholics
Alcoholism
Alcoholism - blood
Analysis of Variance
Buspirone
Buspirone - pharmacology
Humans
Hydrocortisone - blood
Male
Middle Aged
Plasma cortisol level
Receptor status
Sensitivity
Temperance
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Zusammenfassung:We evaluated cortisol response to buspirone in extended abstinent alcoholic patients to determine 5-HT1A receptor sensitivity in alcoholism. Alcoholic patients were inpatients with an extended abstinent period of at least 3 months. Alcoholics had a significantly lower cortisol level than did the normal controls from 60 min through to 150 min after administration of 30 mg buspirone. Our results show that cortisol response to buspirone was significantly decreased in alcoholic patients compared to normal controls, reflecting decreased 5-HT1A receptor sensitivity.
ISSN:0735-0414
1464-3502
1464-3502
DOI:10.1093/alcalc/agh068