Neonatal Tolerance Revisited: Turning on Newborn T Cells with Dendritic Cells

For some time it has been thought that antigenic challenge in neonatal life is a tolerogenic rather than immunogenic event. Reexamination of the classic neonatal tolerance experiments of Billingham, Brent, and Medawar showed that tolerance is not an intrinsic property of the newborn immune system, b...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1996-03, Vol.271 (5256), p.1723-1726
Hauptverfasser:	Ridge, John Paul, Fuchs, Ephraim J., Matzinger, Polly
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Animals Animals, Newborn - immunology Antigen presenting cells Antigens B-Lymphocytes - immunology Babies Biocompatibility Biological and medical sciences Cytotoxicity Tests, Immunologic Cytotoxicity, Immunologic Dendrites Dendritic cells Dendritic Cells - immunology Donors Exercise tolerance Female Females Fundamental and applied biological sciences. Psychology Fundamental immunology H-Y Antigen - immunology Immune system Immune Tolerance Immunity (Disease) Immunization Immunobiology Immunological tolerance Inoculum Logical Thinking Lymphatic system Male Males Mice Mice, Inbred C57BL Neonates Neurons Newborns Priming Self Tolerance Spleen cells T lymphocytes T-Lymphocytes - immunology Transplantation tolerance
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Beschreibung
Zusammenfassung:	For some time it has been thought that antigenic challenge in neonatal life is a tolerogenic rather than immunogenic event. Reexamination of the classic neonatal tolerance experiments of Billingham, Brent, and Medawar showed that tolerance is not an intrinsic property of the newborn immune system, but that the nature of the antigen-presenting cell determines whether the outcome is neonatal tolerance or immunization.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.271.5256.1723