Translocation of Single-Stranded DNA Through Single-Walled Carbon Nanotubes

We report the fabrication of devices in which one single-walled carbon nanotube spans a barrier between two fluid reservoirs, enabling direct electrical measurement of ion transport through the tube. A fraction of the tubes pass anomalously high ionic currents. Electrophoretic transport of small sin...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 2010, Vol.327 (5961), p.64-67
Hauptverfasser: Liu, Haitao, He, Jin, Tang, Jinyao, Liu, Hao, Pang, Pei, Cao, Di, Krstic, Predrag, Joseph, Sony, Lindsay, Stuart, Nuckolls, Colin
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Sprache:eng
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Zusammenfassung:We report the fabrication of devices in which one single-walled carbon nanotube spans a barrier between two fluid reservoirs, enabling direct electrical measurement of ion transport through the tube. A fraction of the tubes pass anomalously high ionic currents. Electrophoretic transport of small single-stranded DNA oligomers through these tubes is marked by large transient increases in ion current and was confirmed by polymerase chain reaction analysis. Each current pulse contains about 10⁷ charges, an enormous amplification of the translocated charge. Carbon nanotubes simplify the construction of nanopores, permit new types of electrical measurements, and may open avenues for control of DNA translocation.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1181799