Biodegradation of the analgesic naproxen by Trametes versicolor and identification of intermediates using HPLC-DAD-MS and NMR

The white-rot fungus Trametes vesicolor degraded naproxen (10 mg L −1) in a liquid medium to non-detectable levels after 6 h. When naproxen was added in the range of concentrations typically found in the environment (55 μg L −1), it was almost completely degraded (95%) after 5 h. In vitro degradatio...

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Veröffentlicht in:	Bioresource technology 2010-04, Vol.101 (7), p.2159-2166
Hauptverfasser:	Marco-Urrea, Ernest, Pérez-Trujillo, Miriam, Blánquez, Paqui, Vicent, Teresa, Caminal, Gloria
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliivibrio fischeri - drug effects Analgesics - chemistry Analgesics - isolation & purification Analgesics - toxicity Biodegradation, Environmental - drug effects Biological and medical sciences Biotechnology Chromatography, High Pressure Liquid Culture Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Degradation Fundamental and applied biological sciences. Psychology Fungi Inhibitors Laccase Laccase - metabolism Liquids Magnetic Resonance Spectroscopy Mass Spectrometry - methods Metabolic Networks and Pathways - drug effects Naproxen Naproxen - analogs & derivatives Naproxen - chemistry Naproxen - isolation & purification Naproxen - toxicity NMR Nuclear magnetic resonance Time Factors Toxicity Tests Trametes Trametes - drug effects Trametes - enzymology Trametes - metabolism Trametes versicolor Triazoles - pharmacology
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