Biodistribution of 1.4- and 18-nm Gold Particles in Rats

1.4‐nm gold nanoparticles (NPs) are observed to cross the air/blood barrier of the lungs much more efficiently than 18‐nm gold NPs (see figure). The NP accumulation pattern in the secondary‐target organs differs strongly from those seen after direct intravenous injection. From this, it is hypothesiz...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2008-12, Vol.4 (12), p.2108-2111
Hauptverfasser:	Semmler-Behnke, Manuela, Kreyling, Wolfgang G., Lipka, Jens, Fertsch, Stefanie, Wenk, Alexander, Takenaka, Shinji, Schmid, Günter, Brandau, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals biodistribution Female Gold Compounds - administration & dosage Gold Compounds - pharmacokinetics gold nanoparticles Metal Nanoparticles - administration & dosage Metal Nanoparticles - chemistry Particle Size Pharmacokinetics Rats Rats, Inbred WKY size dependency toxicology translocation
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	1.4‐nm gold nanoparticles (NPs) are observed to cross the air/blood barrier of the lungs much more efficiently than 18‐nm gold NPs (see figure). The NP accumulation pattern in the secondary‐target organs differs strongly from those seen after direct intravenous injection. From this, it is hypothesized that NPs interact dynamically with proteins and cells, which determines their accumulation in the various organs.
ISSN:	1613-6810 1613-6829
DOI:	10.1002/smll.200800922