Recognition of thymine•adenine base pairs by guanine in a pyrimidine triple helix motif

Recognition of thymine•adenine base pairs by guanine in a pyrimidine triple helix motif

Oligonucleotide recognition offers a powerful chemical approach for the sequence-specific binding of double-helical DNA. In the pyrimidine-Hoogsteen model, a binding size of 15 homopurine base pairs affords 30 discrete sequence-specific hydrogen bonds to duplex DNA.

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Bibliographische Detailangaben
Veröffentlicht in:Science (American Association for the Advancement of Science) 1989-09, Vol.245 (4921), p.967-971
Hauptverfasser: GRIFFIN, L. C, DERVAN, P. B
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Analytical, structural and metabolic biochemistry
Base sequence
Biological and medical sciences
DNA
Fundamental and applied biological sciences. Psychology
Genetics
Guanine
Nucleic acids
Nucleic bases, nucleotides
Nucleotide sequence
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Beschreibung
Zusammenfassung:Oligonucleotide recognition offers a powerful chemical approach for the sequence-specific binding of double-helical DNA. In the pyrimidine-Hoogsteen model, a binding size of 15 homopurine base pairs affords 30 discrete sequence-specific hydrogen bonds to duplex DNA.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.2549639