Multiple Lyotropic Polymorphism of a Poly(ethylene glycol)-Peptide Conjugate in Aqueous Solution

Multiple Lyotropic Polymorphism of a Poly(ethylene glycol)-Peptide Conjugate in Aqueous Solution

Nematic and hexagonal columnar liquid crystal phase formation by a PEG–peptide conjugate is reported. The results are relevant to peptide–polymer conjugates and bionanomaterial self‐assembly (with relevance to PEGylated peptides used in therapeutic applications). The use of modified fragments of the...

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Veröffentlicht in:Advanced materials (Weinheim) 2008-12, Vol.20 (23), p.4394-4397
Hauptverfasser: Hamley, Ian W., Krysmann, Marta J., Castelletto, Valeria, Noirez, Laurence
Format: Artikel
Sprache:eng
Schlagworte:
hybrid materials
liquid crystals
peptides
polymers
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Zusammenfassung:Nematic and hexagonal columnar liquid crystal phase formation by a PEG–peptide conjugate is reported. The results are relevant to peptide–polymer conjugates and bionanomaterial self‐assembly (with relevance to PEGylated peptides used in therapeutic applications). The use of modified fragments of the amyloid beta peptide is especially interesting with respect to amyloid fibrillization and its control.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200800266