Comparison between the self-assembling behaviors of PLLA-PEO-PLLA triblock copolymers and PLLA-PEO-PPO-PEO-PLLA pentablock copolymers

Poly(L-lactic acids) (PLLAs) were grafted to both ends of poly(ethylene oxide) (PEO) to produce biocompatible amphiphilic PLLA-PEO-PLLA triblock copolymers. The self-assembling behaviors of two PLLA-PEO-PLLA copolymers in aqueous solutions were examined by Dynamic Light Scattering and Transmission E...

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Veröffentlicht in:	Journal of applied polymer science 2009-03, Vol.111 (5), p.2445-2451
Hauptverfasser:	Xiong, Xiang Yuan, Li, Zi Ling, Tam, Kam Chiu, Li, Yu Ping, Leng, Jin Quan, Chen, Hai Qin, Wang, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied sciences biocompatibility Biological and medical sciences block copolymers Exact sciences and technology Medical sciences Organic polymers Physicochemistry of polymers Properties and characterization self-assembly Solution and gel properties Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments vesicles
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Beschreibung
Zusammenfassung:	Poly(L-lactic acids) (PLLAs) were grafted to both ends of poly(ethylene oxide) (PEO) to produce biocompatible amphiphilic PLLA-PEO-PLLA triblock copolymers. The self-assembling behaviors of two PLLA-PEO-PLLA copolymers in aqueous solutions were examined by Dynamic Light Scattering and Transmission Electron Microscopic techniques. PLLA-PEO-PLLA formed spherical micelles, whereas PLLA-PEO-PPO-PEO-PLLA pentablock copolymers were reported to produce vesicles. It is believed that the PPO segment within the PLLA-PEO-PPO-PEO-PLLA pentablock copolymers has a dominant role in the formation of vesicles.
ISSN:	0021-8995 1097-4628
DOI:	10.1002/app.29278