Preventive effect of Tinospora cordifolia against high-fructose diet-induced insulin resistance and oxidative stress in male Wistar rats

High intake of dietary fructose exerts a number of adverse metabolic effects. The aim of the present study was to investigate whether aqueous extract of Tinospora cordifolia stem (TCAE) alleviates high-fructose diet-induced insulin resistance and oxidative stress in rats. High-fructose diet (66% of...

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Veröffentlicht in:	Food and chemical toxicology 2009-09, Vol.47 (9), p.2224-2229
Hauptverfasser:	Reddy, Singareddy Sreenivasa, Ramatholisamma, Pasurla, Karuna, Rasineni, Saralakumari, Desireddy
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals antioxidant activity Antioxidants Antioxidants - pharmacology Biological and medical sciences blood glucose blood lipids carbonyl compounds catalase Diabetes mellitus Diabetes. Impaired glucose tolerance diet diet-related diseases Disease Models, Animal Drug Antagonism Endocrine pancreas. Apud cells (diseases) Endocrinopathies enzyme activity Etiopathogenesis. Screening. Investigations. Target tissue resistance experimental diets fructose Fructose - adverse effects Fructose - metabolism General pharmacology glucose tolerance Glucose Tolerance Test glutathione Glutathione - metabolism glutathione peroxidase glutathione reductase (NADPH) glutathione transferase human diseases human nutrition hyperglycemia hyperinsulinemia hypertriglyceridemia insulin insulin resistance lipid peroxidation Lipid Peroxidation - drug effects Lipid Peroxidation - physiology liver Liver - drug effects Liver - metabolism Male Medical sciences Medicinal plants Metabolic diseases Metabolic syndrome Metabolic Syndrome - etiology Metabolic Syndrome - metabolism Metabolic Syndrome - prevention & control Miscellaneous Oral glucose tolerance test Other metabolic disorders Oxidative Stress - drug effects Oxidative Stress - physiology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Extracts - chemistry Plant Extracts - pharmacology Plant poisons toxicology Protein Carbonylation - drug effects Rats Rats, Wistar superoxide dismutase Sweetener Tinospora Tinospora - chemistry Tinospora cordifolia Toxicology triacylglycerols
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Zusammenfassung:	High intake of dietary fructose exerts a number of adverse metabolic effects. The aim of the present study was to investigate whether aqueous extract of Tinospora cordifolia stem (TCAE) alleviates high-fructose diet-induced insulin resistance and oxidative stress in rats. High-fructose diet (66% of fructose) and TCAE (400mg/kg/day) were given simultaneously for a period of 60days. Fructose fed rats showed hyperglycemia, hyperinsulinemia, hypertriglyceridemia, impaired glucose tolerance and impaired insulin sensitivity (P
ISSN:	0278-6915 1873-6351
DOI:	10.1016/j.fct.2009.06.008