Copper‐Catalyzed N‐Arylation of Hindered Substrates Under Mild Conditions

Copper‐Catalyzed N‐Arylation of Hindered Substrates Under Mild Conditions

A mild, efficient method utilizing a copper‐diamine catalyst at room temperature is reported for the coupling of hindered imidazoles with unsubstituted, ortho‐substituted, and bis‐ortho‐substituted boronic acids in good to excellent yields. Aryl halides do not reaction under these conditions permitt...

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Veröffentlicht in:Advanced synthesis & catalysis 2009-04, Vol.351 (6), p.931-937
Hauptverfasser: Wentzel, Michael T., Hewgley, J. Brian, Kamble, Rajesh M., Wall, Philip D., Kozlowski, Marisa C.
Format: Artikel
Sprache:eng
Schlagworte:
boronic acids
copper catalysis
nitrogen heterocycles
N‐arylation
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Beschreibung
Zusammenfassung:A mild, efficient method utilizing a copper‐diamine catalyst at room temperature is reported for the coupling of hindered imidazoles with unsubstituted, ortho‐substituted, and bis‐ortho‐substituted boronic acids in good to excellent yields. Aryl halides do not reaction under these conditions permitting sequential N‐arylation reactions.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200800730