Synthesis and primary biological evaluation of ReN-NEMPTDD

Synthesis and primary biological evaluation of ReN-NEMPTDD

A new nitrido-Re complex, ReN-NEMPTDD, was synthesized through a modified method in high yield. This complex was stable in vitro. The biodistribution in normal mice showed that this ReN complex accumulated in the liver and was eliminated quickly from almost all organs. VX2 carcinoma was grown in the...

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Veröffentlicht in:Journal of radioanalytical and nuclear chemistry 2008-08, Vol.277 (2), p.365-369
Hauptverfasser: Wang, Guan-Quan, Zhang, Ji, Luo, Shun-Zhong, Wang, Na, Wei, Hong-Yuan, Wang, Wen-Jin, Yang, Yu-Qing, Liu, Guo-Ping, Yu, Xiao-Qi
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Sprache:eng
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Zusammenfassung:A new nitrido-Re complex, ReN-NEMPTDD, was synthesized through a modified method in high yield. This complex was stable in vitro. The biodistribution in normal mice showed that this ReN complex accumulated in the liver and was eliminated quickly from almost all organs. VX2 carcinoma was grown in the livers of rabbits. Transcatheter arterial embolization (TAE) was performed using ReN-NEMPTDD/lipiodol solution. The SPECT images showed that the lipiodol solution could be concentrated in the tumor for about 12 hours. These results indicated that ReN-NEMPTDD/lipiodol could be a potential radiopharmaceutical for liver cancer.
ISSN:0236-5731
DOI:10.1007/s10967-007-7033-2