Thermal characterization of indinavir sulfate using TG, DSC and DSC-photovisual

The object of the present work is to study the thermal characteristics of indinavir sulfate and to evaluate the quality of the raw materials. Indinavir A, B, C and reference samples were obtained from different suppliers and submitted to TG, DSC and DSC-photovisual analyses. TG/DTG curves indicated...

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Veröffentlicht in:	Journal of thermal analysis and calorimetry 2009-03, Vol.95 (3), p.965-968
Hauptverfasser:	Ferreira da Silva, Rosali Maria, Morais de Medeiros, Flávia Patrícia, Nascimento, T. G., Macêdo, R. O., Neto, P. J. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical Chemistry Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Chemistry Chemistry and Materials Science General pharmacology Inorganic Chemistry Measurement Science and Instrumentation Medical sciences Pharmacology. Drug treatments Physical Chemistry Polymer Sciences Regular Papers
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Zusammenfassung:	The object of the present work is to study the thermal characteristics of indinavir sulfate and to evaluate the quality of the raw materials. Indinavir A, B, C and reference samples were obtained from different suppliers and submitted to TG, DSC and DSC-photovisual analyses. TG/DTG curves indicated a desolvation and dehydration processes and were confirmed by DSC. According to the DSC curves the fusion took place at about 141–142°C for indinavir C and Reference sample B and about 146–149°C for the others. DSC-photovisual showed insoluble raw materials for indinavir C at 160°C. Indinavir sulfate is highly hygroscopic drug which requires attention during storage and manufacture by pharmaceutical industry.
ISSN:	1388-6150 1588-2926 1572-8943
DOI:	10.1007/s10973-008-8912-7