Cell micro-arrays from surface-attached peptide-polymer monolayers

We introduce the design of a chip for the controlled adhesion of anchorage‐dependent cells. A hybrid copolymer, comprising the peptide cell‐recognition motif RGD, attached to a protein‐repellent poly(dimethylacrylamide) PDMAA polymer is used in a lithography process to implement a chemical microstru...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Physica status solidi. A, Applications and materials science Applications and materials science, 2009-03, Vol.206 (3), p.468-473
Hauptverfasser:	Petersen, Sönke, Loschonsky, Sidar, Prucker, Oswald, Rühe, Jürgen, Biesalski, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	87.85.dh 87.85.jf Biological and medical sciences Cell interactions, adhesion Fundamental and applied biological sciences. Psychology Molecular and cellular biology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We introduce the design of a chip for the controlled adhesion of anchorage‐dependent cells. A hybrid copolymer, comprising the peptide cell‐recognition motif RGD, attached to a protein‐repellent poly(dimethylacrylamide) PDMAA polymer is used in a lithography process to implement a chemical microstructure on planar surfaces. The characterization of the surface‐attached film along with a first study of its performance in cell adhesion assays is presented. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
ISSN:	1862-6300 0031-8965 1862-6319
DOI:	10.1002/pssa.200880484