Combinatorial Polymer Scaffold Libraries for Screening Cell-Biomaterial Interactions in 3D

Combinatorial Polymer Scaffold Libraries for Screening Cell-Biomaterial Interactions in 3D

A combinatorial method for screening cell–biomaterial interactions in 3D is presented; polymeric, salt‐leached scaffolds with varied composition and properties are present in a 96‐well plate. Previous high‐throughput approaches for screening cell–material interactions have focused on planar 2D surfa...

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Veröffentlicht in:Advanced materials (Weinheim) 2008-06, Vol.20 (11), p.2037-2043
Hauptverfasser: Yang, Yanyin, Bolikal, Durgadas, Becker, Matthew L., Kohn, Joachim, Zeiger, Diana N., Simon Jr, Carl G.
Format: Artikel
Sprache:eng
Schlagworte:
biomaterials
cell proliferation
cell screening
combinatorial methods
polymer scaffolds
screening
tyrosine-derived polycarbonates
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Zusammenfassung:A combinatorial method for screening cell–biomaterial interactions in 3D is presented; polymeric, salt‐leached scaffolds with varied composition and properties are present in a 96‐well plate. Previous high‐throughput approaches for screening cell–material interactions have focused on planar 2D surfaces or films. However, biomaterials are commonly used in a 3D scaffold format and cells behave more physiologically when cultured in 3D.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200702088