Optimization of systemic nasal drug delivery with pharmaceutical excipients

Optimization of systemic nasal drug delivery with pharmaceutical excipients

The nasal drug route provides a viable alternative for many drugs which are presently administered via parenteral and oral routes. Nasal drug absorption is optimized by improving on formulation excipients, designing various types of novel nasal dosage forms, and understanding the mechanisms of nasal...

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Veröffentlicht in:Advanced drug delivery reviews 1998-01, Vol.29 (1), p.117-133
Hauptverfasser: Behl, C.R, Pimplaskar, H.K, Sileno, A.P, Xia, W.J, Gries, W.J, deMeireles, J.C, Romeo, V.D
Format: Artikel
Sprache:eng
Schlagworte:
Absorption
Absorption enhancers
Absorption factors
Absorption optimizers
Bile salts
Gels
Intranasal drug delivery
Nasal delivery
Nasal gels
Nasal powders
Nasal solutions
Pharmacokinetics
Physical chemical properties
Powders
Salts
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Beschreibung
Zusammenfassung:The nasal drug route provides a viable alternative for many drugs which are presently administered via parenteral and oral routes. Nasal drug absorption is optimized by improving on formulation excipients, designing various types of novel nasal dosage forms, and understanding the mechanisms of nasal drug absorption.
ISSN:0169-409X
1872-8294
DOI:10.1016/S0169-409X(97)00064-1