New liposome development: Lipid/DNA complexes as an intermediate in the preparation of particles for gene transfer: an alternative to cationic liposome/DNA aggregates

When cationic liposomes are mixed with plasmid DNA an aggregation reaction occurs. The heterogeneous membrane structures which arise following this reaction are dependent on liposomal lipid composition, liposome/DNA ratio as well as the presence of added salts or proteins. The resulting structures a...

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Veröffentlicht in:Advanced drug delivery reviews 1997-03, Vol.24 (2-3), p.275-290
Hauptverfasser: Bally, Marcel B, Zhang, Yuan-Peng, Wong, Frances M P, Kong, Spencer, Wasan, Ellen, Reimer, Dorothy L
Format: Artikel
Sprache:eng
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