Improving mixing in microbioreactors

This paper describes a possible active mixing method for a 30 μ l microbioreactor that was designed, simulated and tested. Pressure based recycle flow was investigated in a cylindrical microreactor for mixing efficiency. Based on the computational fluid dynamics (CFD) simulation results and the requ...

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Veröffentlicht in:	Chemical engineering science 2008-06, Vol.63 (11), p.3036-3046
Hauptverfasser:	Li, X., van der Steen, G., van Dedem, G.W.K., van der Wielen, L.A.M., van Leeuwen, M., van Gulik, W.M., Heijnen, J.J., Krommenhoek, E.E., Gardeniers, J.G.E., van den Berg, A., Ottens, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied sciences Chemical engineering Computational fluid dynamics (CFD) Exact sciences and technology Microbioreactor Microfluidics Micromixing Rayleigh–Bénard convection Reactors Recycle flow mixing
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Beschreibung
Zusammenfassung:	This paper describes a possible active mixing method for a 30 μ l microbioreactor that was designed, simulated and tested. Pressure based recycle flow was investigated in a cylindrical microreactor for mixing efficiency. Based on the computational fluid dynamics (CFD) simulation results and the requirements of the application, the recycle flow mixing method proved to be suitable as a method to induce sufficient mixing in the microbioreactor. This was verified experimentally using image analysis of dye distribution behavior.
ISSN:	0009-2509 1873-4405
DOI:	10.1016/j.ces.2008.02.036