Water-soluble aldehyde-bearing polymers of 2-deoxy-2-methacrylamido-D-glucose for bone tissue engineering

In this study the methods of synthesis of hydrophilic aldehyde-bearing polymers and copolymers based on 2-deoxy-2-methacrylamido-D-glucose have been developed. Polymers with controllable aldehyde group content were synthesized via free-radical polymerization and subsequent polymeranalogous modificat...

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Veröffentlicht in:Journal of applied polymer science 2008-05, Vol.108 (4), p.2386-2397
Hauptverfasser: Korzhikov, Victor A, Diederichs, Solvig, Nazarova, Olga V, Vlakh, Evgenia G, Kasper, Cornelia, Panarin, Evgeny F, Tennikova, Tatiana B
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Sprache:eng
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Zusammenfassung:In this study the methods of synthesis of hydrophilic aldehyde-bearing polymers and copolymers based on 2-deoxy-2-methacrylamido-D-glucose have been developed. Polymers with controllable aldehyde group content were synthesized via free-radical polymerization and subsequent polymeranalogous modification. The water-soluble polymers obtained were investigated in view of their capacity to be adsorbed on two commercial mineral supports used in bone tissue engineering. Besides, cytotoxicity of synthesized polymers was tested.
ISSN:0021-8995
1097-4628
DOI:10.1002/app.27292