Toxicity of lapachol and isolapachol and their potassium salts against Biomphalaria glabrata, Schistosoma mansoni cercariae, Artemia salina and Tilapia nilotica
The toxicity of soluble derivatives (potassium salt) of lapachol and isolapachol in different stages of the life cycle of Schistosoma mansoni is evaluated. The potassium salts of isolapachol and lapachol showed significant molluscicidal activity against the adult snail (LC 90
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| Veröffentlicht in: | Acta tropica 2002-07, Vol.83 (1), p.43-47 |
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| container_title | Acta tropica |
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| creator | Lima, Nadja Maria Fernandes dos Santos, Aldenir Feitosa Porfı́rio, Zenaldo Goulart, Marı́lia O.F Sant'Ana, Antônio Euzébio G |
| description | The toxicity of soluble derivatives (potassium salt) of lapachol and isolapachol in different stages of the life cycle of
Schistosoma mansoni is evaluated. The potassium salts of isolapachol and lapachol showed significant molluscicidal activity against the adult snail (LC
90 |
| doi_str_mv | 10.1016/S0001-706X(02)00055-4 |
| format | Article |
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Schistosoma mansoni is evaluated. The potassium salts of isolapachol and lapachol showed significant molluscicidal activity against the adult snail (LC
90<7 ppm) and snail egg masses (LC
90<3 ppm). Cercaricidal assays revealed strong activities for both compounds. Lethality assays against brine shrimp eggs (
Artemia salina Leach) indicated very high toxicity for the potassium salt of isolapachol (LC
90=1.54 ppm), differently from the potassium salt of lapachol that can be considered non toxic (LC
90=176.3 ppm). The same tendency is observed with piscicidal activity, for which the isolapachol salt has showed higher toxicity. The obtained selectivity ratios concerning LC
50 and LC
90 for lapachol, in relation to
Tilapia nilotica lethality assay are 2.33 and 1.26, respectively. Despite the piscicidal toxicity, the use of the salt of lapachol can be recommended for field tests in Schistosomiasis, with caution.</description><identifier>ISSN: 0001-706X</identifier><identifier>EISSN: 1873-6254</identifier><identifier>DOI: 10.1016/S0001-706X(02)00055-4</identifier><identifier>PMID: 12062792</identifier><identifier>CODEN: ACTRAQ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Anthelmintics - toxicity ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiparasitic agents ; Artemia - drug effects ; Biological and medical sciences ; Biomphalaria - drug effects ; Biomphalaria glabrata ; Cercaricide ; Confidence Intervals ; Isolapachol potassium salt ; Lapachol potassium salt ; Medical sciences ; Molluscacides - toxicity ; Naphthoquinones - toxicity ; Parasitic Sensitivity Tests ; Pharmacology. Drug treatments ; Piscicide ; Schistosoma mansoni - drug effects ; Snail control ; Structure-Activity Relationship ; Tilapia ; Tropical medicine</subject><ispartof>Acta tropica, 2002-07, Vol.83 (1), p.43-47</ispartof><rights>2002 Elsevier Science B.V.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-69c7b5d407fc194ac05df3e3950f3b5c6a5632f0359dcbd11f2662998aa9d7123</citedby><cites>FETCH-LOGICAL-c422t-69c7b5d407fc194ac05df3e3950f3b5c6a5632f0359dcbd11f2662998aa9d7123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0001-706X(02)00055-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13721825$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12062792$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lima, Nadja Maria Fernandes</creatorcontrib><creatorcontrib>dos Santos, Aldenir Feitosa</creatorcontrib><creatorcontrib>Porfı́rio, Zenaldo</creatorcontrib><creatorcontrib>Goulart, Marı́lia O.F</creatorcontrib><creatorcontrib>Sant'Ana, Antônio Euzébio G</creatorcontrib><title>Toxicity of lapachol and isolapachol and their potassium salts against Biomphalaria glabrata, Schistosoma mansoni cercariae, Artemia salina and Tilapia nilotica</title><title>Acta tropica</title><addtitle>Acta Trop</addtitle><description>The toxicity of soluble derivatives (potassium salt) of lapachol and isolapachol in different stages of the life cycle of
Schistosoma mansoni is evaluated. The potassium salts of isolapachol and lapachol showed significant molluscicidal activity against the adult snail (LC
90<7 ppm) and snail egg masses (LC
90<3 ppm). Cercaricidal assays revealed strong activities for both compounds. Lethality assays against brine shrimp eggs (
Artemia salina Leach) indicated very high toxicity for the potassium salt of isolapachol (LC
90=1.54 ppm), differently from the potassium salt of lapachol that can be considered non toxic (LC
90=176.3 ppm). The same tendency is observed with piscicidal activity, for which the isolapachol salt has showed higher toxicity. The obtained selectivity ratios concerning LC
50 and LC
90 for lapachol, in relation to
Tilapia nilotica lethality assay are 2.33 and 1.26, respectively. Despite the piscicidal toxicity, the use of the salt of lapachol can be recommended for field tests in Schistosomiasis, with caution.</description><subject>Animals</subject><subject>Anthelmintics - toxicity</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiparasitic agents</subject><subject>Artemia - drug effects</subject><subject>Biological and medical sciences</subject><subject>Biomphalaria - drug effects</subject><subject>Biomphalaria glabrata</subject><subject>Cercaricide</subject><subject>Confidence Intervals</subject><subject>Isolapachol potassium salt</subject><subject>Lapachol potassium salt</subject><subject>Medical sciences</subject><subject>Molluscacides - toxicity</subject><subject>Naphthoquinones - toxicity</subject><subject>Parasitic Sensitivity Tests</subject><subject>Pharmacology. Drug treatments</subject><subject>Piscicide</subject><subject>Schistosoma mansoni - drug effects</subject><subject>Snail control</subject><subject>Structure-Activity Relationship</subject><subject>Tilapia</subject><subject>Tropical medicine</subject><issn>0001-706X</issn><issn>1873-6254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd2KFDEQhYMo7uzqIyi5UVbY1iTdSU9fybr4Bwte7Ajehep0eqck3RlTGXHfxkc184OLV16FE75Tp6jD2DMpXkshzZsbIYSsWmG-nQv1qgitq-YBW8hlW1dG6eYhW_xFTtgp0feiVKvVY3YilTCq7dSC_V7FX-gw3_E48gAbcOsYOMwDR4r_6Lz2mPgmZiDC7cQJQiYOt4AzZf4O47RZQ4CEwG8D9AkyXPAbt0bKkeIEfIKZ4ozc-eR2mL_glyn7qRjKLJxhH7PCklq-Zgwxo4Mn7NEIgfzT43vGvn54v7r6VF1_-fj56vK6co1SuTKda3s9NKIdnewacEIPY-3rToux7rUzoE2tRlHrbnD9IOWojFFdtwTohlaq-oy9PMzdpPhj6ynbCcn5EGD2cUu2Vq00ctkUUB9AlyJR8qPdJJwg3Vkp7K4au6_G7u5uhbL7auzO9_wYsO0nP9y7jl0U4MURAHIQxgSzQ7rn6lbJpdKFe3vgfDnHT_TJkkM_Oz9g8i7bIeJ_VvkDWpquSw</recordid><startdate>20020701</startdate><enddate>20020701</enddate><creator>Lima, Nadja Maria Fernandes</creator><creator>dos Santos, Aldenir Feitosa</creator><creator>Porfı́rio, Zenaldo</creator><creator>Goulart, Marı́lia O.F</creator><creator>Sant'Ana, Antônio Euzébio G</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>20020701</creationdate><title>Toxicity of lapachol and isolapachol and their potassium salts against Biomphalaria glabrata, Schistosoma mansoni cercariae, Artemia salina and Tilapia nilotica</title><author>Lima, Nadja Maria Fernandes ; dos Santos, Aldenir Feitosa ; Porfı́rio, Zenaldo ; Goulart, Marı́lia O.F ; Sant'Ana, Antônio Euzébio G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-69c7b5d407fc194ac05df3e3950f3b5c6a5632f0359dcbd11f2662998aa9d7123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Anthelmintics - toxicity</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiparasitic agents</topic><topic>Artemia - drug effects</topic><topic>Biological and medical sciences</topic><topic>Biomphalaria - drug effects</topic><topic>Biomphalaria glabrata</topic><topic>Cercaricide</topic><topic>Confidence Intervals</topic><topic>Isolapachol potassium salt</topic><topic>Lapachol potassium salt</topic><topic>Medical sciences</topic><topic>Molluscacides - toxicity</topic><topic>Naphthoquinones - toxicity</topic><topic>Parasitic Sensitivity Tests</topic><topic>Pharmacology. Drug treatments</topic><topic>Piscicide</topic><topic>Schistosoma mansoni - drug effects</topic><topic>Snail control</topic><topic>Structure-Activity Relationship</topic><topic>Tilapia</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lima, Nadja Maria Fernandes</creatorcontrib><creatorcontrib>dos Santos, Aldenir Feitosa</creatorcontrib><creatorcontrib>Porfı́rio, Zenaldo</creatorcontrib><creatorcontrib>Goulart, Marı́lia O.F</creatorcontrib><creatorcontrib>Sant'Ana, Antônio Euzébio G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Acta tropica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lima, Nadja Maria Fernandes</au><au>dos Santos, Aldenir Feitosa</au><au>Porfı́rio, Zenaldo</au><au>Goulart, Marı́lia O.F</au><au>Sant'Ana, Antônio Euzébio G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toxicity of lapachol and isolapachol and their potassium salts against Biomphalaria glabrata, Schistosoma mansoni cercariae, Artemia salina and Tilapia nilotica</atitle><jtitle>Acta tropica</jtitle><addtitle>Acta Trop</addtitle><date>2002-07-01</date><risdate>2002</risdate><volume>83</volume><issue>1</issue><spage>43</spage><epage>47</epage><pages>43-47</pages><issn>0001-706X</issn><eissn>1873-6254</eissn><coden>ACTRAQ</coden><abstract>The toxicity of soluble derivatives (potassium salt) of lapachol and isolapachol in different stages of the life cycle of
Schistosoma mansoni is evaluated. The potassium salts of isolapachol and lapachol showed significant molluscicidal activity against the adult snail (LC
90<7 ppm) and snail egg masses (LC
90<3 ppm). Cercaricidal assays revealed strong activities for both compounds. Lethality assays against brine shrimp eggs (
Artemia salina Leach) indicated very high toxicity for the potassium salt of isolapachol (LC
90=1.54 ppm), differently from the potassium salt of lapachol that can be considered non toxic (LC
90=176.3 ppm). The same tendency is observed with piscicidal activity, for which the isolapachol salt has showed higher toxicity. The obtained selectivity ratios concerning LC
50 and LC
90 for lapachol, in relation to
Tilapia nilotica lethality assay are 2.33 and 1.26, respectively. Despite the piscicidal toxicity, the use of the salt of lapachol can be recommended for field tests in Schistosomiasis, with caution.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>12062792</pmid><doi>10.1016/S0001-706X(02)00055-4</doi><tpages>5</tpages></addata></record> |
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| ispartof | Acta tropica, 2002-07, Vol.83 (1), p.43-47 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Anthelmintics - toxicity Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Artemia - drug effects Biological and medical sciences Biomphalaria - drug effects Biomphalaria glabrata Cercaricide Confidence Intervals Isolapachol potassium salt Lapachol potassium salt Medical sciences Molluscacides - toxicity Naphthoquinones - toxicity Parasitic Sensitivity Tests Pharmacology. Drug treatments Piscicide Schistosoma mansoni - drug effects Snail control Structure-Activity Relationship Tilapia Tropical medicine |
| title | Toxicity of lapachol and isolapachol and their potassium salts against Biomphalaria glabrata, Schistosoma mansoni cercariae, Artemia salina and Tilapia nilotica |
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