Antibacterial activities of a few prepared derivatives of oleanolic acid and of other natural triterpenic compounds

Oxidizing, phosphorus, ester and amide derivatives of oleanolic acid 1 have been prepared. The antibacterial activity of compound 1, isolated from the fruit barks of Periploca laevigata (Asclepiadaceae), and its derivatives have been tested using Tween-80 as complex agent to form a water-soluble triterpenes. The same activity of maslinic acid acetate 2, beta-amyrin 3, and its acetylated derivative 3a (Fig.1), isolated from the same source as that of oleanolic acid 1, have also been investigated.