Synthesis of Peptide/Polymer Conjugates by Solution ATRP of Butylacrylate Using an Initiator-Modified Cyclic D-alt-L-Peptide

Peptide/polymer hybrid molecules consisting of poly(butylacrylate) chains, covalently attached to a cyclic D‐alt‐L‐octapeptide, were prepared by the in situ ATRP of butylacrylate using a cyclic peptide that was modified at three distinct positions with an initiator group. The apparent molar mass of the peptide/PBA hybrid molecules could be controlled through adjusting the reaction conversion. The hybrid molecule showed a solvent induced self‐assembly, which yielded rod‐like nanostructures having a core shell morphology with an internal beta‐sheet peptide assembly surrounded by a soft PBA exterior.