Polymer-Supported Hantzsch 1,4-Dihydropyridine Ester: An Efficient Biomimetic Hydrogen Source

Polymer-Supported Hantzsch 1,4-Dihydropyridine Ester: An Efficient Biomimetic Hydrogen Source

An efficient synthesis of a polymer‐supported Hantzsch 1,4‐dihydropyridine ester has been developed and its use in a variety of reduction reactions was studied using α,β‐unsaturated aldehydes, imines and an activated benzoquinone as substrates. Reductive amination using the polymer‐supported Hantzsc...

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Veröffentlicht in:Advanced synthesis & catalysis 2008-01, Vol.350 (1), p.54-60
Hauptverfasser: He, Rongjun, Toy, Patrick H., Lam, Yulin
Format: Artikel
Sprache:eng
Schlagworte:
1,4‐dihydropyridine
4-dihydropyridine
biomimetic hydrogen source
Hantzsch ester
polymer-supported reducing agent
reduction
reductive amination
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Zusammenfassung:An efficient synthesis of a polymer‐supported Hantzsch 1,4‐dihydropyridine ester has been developed and its use in a variety of reduction reactions was studied using α,β‐unsaturated aldehydes, imines and an activated benzoquinone as substrates. Reductive amination using the polymer‐supported Hantzsch 1,4‐dihydropyridine ester and a catalytic amount of 1.5 M HCl was found to proceed rapidly and with good yields.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200700344