Wearable Multimodal Optical Analyzers: Physiological Variability and Reproducibility of Measurements

The work is devoted to the study of the physiological variability of the microcirculatory-tissue system (MTS) parameters under normal conditions and during functional tests. The results were obtained in vivo using multimodal wearable analyzers implementing methods of laser Doppler flowmetry and fluorescence spectroscopy. Comprehensive data analysis and calculation of the coefficients of variation of the MTS parameters of the human body for various topographic and anatomical areas of the skin were carried out. The obtained results showed higher values of the coefficient of variation of MTS parameters in the area of the toes and wrists, while the fingers and forehead skin showed lower levers of variation. In all areas of the study, reproducibility of the parameters obtained for the right and left areas of the study is observed.