Studies concerning the chemical immobilization of dendrimers on macroporous polymer matrix

A highly innovative combination of dendrimers with non-biodegradable host polymers (poly(2-hydroxyethyl methacrylate)) (PHEMA) was researched in order to obtain a completely new approach to bone regeneration. This study was aimed at the development of hybrid materials Polymer (PHEMA)-Polyamidoamine dendrimers (PAMAM), as smart biomaterials with Hydroxyapatite (HA) forming ability. Besides the capacity to form HA when implanted, these hybrids are designed with special macroporous interconnected architecture similar to that characteristic to the trabecular bone. The success of the binding of PAMAM on the surface of PHEMA matrix was checked through FTIR analyses. The hybrids will be further characterized and in vitro evaluated with respect to their capacity to initiate HA formation when used as bone grafts with osteoconductive properties.