Small molecules unlock broad-spectrum plant resistance

Small molecules unlock broad-spectrum plant resistance

Toll/interleukin-1 receptor (TIR) domain proteins possess NADase activity and trigger plant immunity via their enzymatic products. Two recent studies have elucidated the mechanism by which TIR NADase-derived 2′cADPR and pRib-AMP/ADP activate EDS1–PAD4–ADR1 (EPA) signalling, thereby inducing immune r...

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Veröffentlicht in:Nature plants 2025-01, Vol.11 (1), p.11-13
Hauptverfasser: Li, Kaihuai, Qiao, Yan, Chen, Huan, Liu, Fengquan
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine
Adenosine diphosphate
Cell death
Cyclic ADP-ribose
Cytokines
Homeostasis
Immune response
Interleukin 1
Investigations
Kinases
Pathogens
Plant immunity
Plant resistance
Rice
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Zusammenfassung:Toll/interleukin-1 receptor (TIR) domain proteins possess NADase activity and trigger plant immunity via their enzymatic products. Two recent studies have elucidated the mechanism by which TIR NADase-derived 2′cADPR and pRib-AMP/ADP activate EDS1–PAD4–ADR1 (EPA) signalling, thereby inducing immune responses in plants.
ISSN:2055-0278
2055-0278
DOI:10.1038/s41477-024-01891-w