F-53B disrupts energy metabolism by inhibiting the V-ATPase-AMPK axis in neuronal cells

6:2 chloro-polyfluorooctane ether sulfonate (F-53B) is considered neurotoxic, but its mechanisms remain unclear. This study aimed to investigate the toxic effects of F-53B on neuronal cells, focusing on the role of the V-ATPase-AMPK axis in the mechanism of abnormal energy metabolism. Mouse astrocyt...

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Veröffentlicht in:	Journal of hazardous materials 2025-01, Vol.487, p.137111, Article 137111
Hauptverfasser:	Zhang, Yue, Li, Tingting, Ding, Xueman, Liu, Li, Ma, Runjiang, Qin, Wenqi, Yan, Chulin, Wang, Chun, Zhang, Jingjing, Keerman, Mulatibieke, Niu, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	F-53B Lysosomal dysfunction Mitochondrial energy metabolism Neurotoxicity V-ATPase-AMPK axis
Online-Zugang:	Volltext
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